Vitamin D, the immune system, and its relationship with diseases

Abstract Background Vitamin D is classified as an immunomodulatory hormone that synthesized because of skin exposure to sunlight. It known come into play during the regulation secretion, immune functions, cell proliferation, and differentiation. Its deficiency can cause many diseases their associated pleiotropic effects. In addition, in relation its eminent function regards adaptive response innate response, vitamin level with tolerance. Methods Literature search prior May 2021 was conducted through selected websites, including MEDLINE, Embase, Web Science, Cochrane Central, www.ClinicalTrials.gov , PubMed, Science Direct, Google Scholar, EFSA. Results found effective for proliferation along role modulator based on presence receptors cells synthesis active metabolite from these cells. D, system modulator, inhibits stimulates A fair number diseases, encompassing autoimmune disorders alongside infectious occur low serum levels. Supplementation has positive effects lessening severity nature disease activity; there exists no consensus dose be used. Conclusion figured out a higher randomized controlled trials are essential evaluate efficacy pertaining clinical cases, treatment duration, type, supplementation pathophysiology functioning, effect administered.